Item 1.01 Entry into a Material Definitive Agreement

On August 11, 2009, we amended our amended and restated senior secured note Highbridge International LLC, to extend the maturity date from January 15, 2010 to July 15, 2010, and terminate Highbridge's redemption rights in the event of a joint venture transaction. In the amendment we commit to exercising our right to sell our auction rate securities (ARS) in accordance with the terms of the rights offering by UBS AG, who sold them to us, and use the proceeds from the sale to redeem the note. If we borrow or raise capital, we will use all or a portion of the funds raised to redeem the note at 110%. We also amended Highbridge's warrants for 1,840,188 shares of our common stock, to change the exercise price to $0.28 per share, and extend the expiration date to five years from the amendment date.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits. No. Description 10.1 Amendment to Amended and Restated Senior Secured Note dated August 11, 2009 between Hythiam, Inc. and Highbridge International LLC 10.2 Amendment to Common Stock Purchase Warrant dated August 11, 2009 between Hythiam, Inc. and Highbridge International LLC 10.3 Amendment to Amended and Restated Warrant to Purchase Common Stock dated August 11, 2009 between Hythiam, Inc. and Highbridge International LLC